Biotin and derivatives
Advanced Chem Tech D-Biotin Amidocaproic acid, Advanced ChemTech
Molecular Weight (g/mol): 357.47
Advanced Chem Tech D-Biotin, Advanced ChemTech
Molecular Weight (g/mol): 244.32
IBA LifeSciences Biotin powder; 5 g
Biotin is a water-soluble B-complex vitamin, also known as vitamin B7 or vitamin H. It binds to the biotin-binding pockets of streptavidin, Strep-Tactin, and Strep-TactinXT with different affinities. As a result, it allows the efficient elution of Strep-tagII or Twin-Strep-tag fusion proteins from Strep-TactinXT, while maintaining the reusability of the resin. It can be used for preparation of Strep-TactinXT elution buffer, Buffer BXT. In addition, biotin can be used for elution of biotinylated proteins from Strep-Tactin, where it binds irreversibly to the resin. Hence, Strep-Tactin cannot be regenerated in this kind of application.
IBA LifeSciences Biotin powder; 2 g
Biotin is a water-soluble B-complex vitamin, also known as vitamin B7 or vitamin H. It binds to the biotin-binding pockets of streptavidin, Strep-Tactin, and Strep-TactinXT with different affinities. As a result, it allows the efficient elution of Strep-tagII or Twin-Strep-tag fusion proteins from Strep-TactinXT, while maintaining the reusability of the resin. It can be used for preparation of Strep-TactinXT elution buffer, Buffer BXT. In addition, biotin can be used for elution of biotinylated proteins from Strep-Tactin, where it binds irreversibly to the resin. Hence, Strep-Tactin cannot be regenerated in this kind of application.
Medchemexpress LLC M-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g/mol | C18H31NO10 | 100 MG
m-PEG6-NHS ester is a non-cleavable, 6-unit polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) activated ester. It provides a hydrophilic spacer and an activated coupling group for selective amine conjugation, and is commonly used in antibody-drug conjugate (ADC) development, PROTAC assembly, and general bioconjugation.
- Non-cleavable 6-unit PEG linker providing a hydrophilic spacer.
- Activated NHS ester for selective amine coupling.
- High purity suitable for bioconjugation (≥97.0%).
- Colorless to light yellow liquid; density approximately 1.21 g/cm3.
- Stable under cold storage: pure form -20°C (3 years) or 4°C (2 years).
- Available in lab-scale (100 mg) up to larger quantities (quote for bulk sizes).
Medchemexpress LLC Bis-PEG25-NHS ester | 2221948-96-3 | MFCD21363290 | 99.8% | 1413.55 | C62H112N2O33 | 25 MG
Bis-PEG25-NHS ester is a PEG/alkyl/ether-based homobifunctional linker containing two N-hydroxysuccinimide (NHS) ester groups, used for conjugation in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs). It is provided as a hydrophilic solid for use in organic solvents and should be stored sealed at -20°C.
- Contains two amine-reactive NHS ester groups for conjugation.
- PEG spacer increases hydrophilicity and solubility in aqueous media.
- Suitable as a cleavable linker for ADC and PROTAC synthesis.
- Provided as a solid with recommended cold, sealed storage to preserve stability.
eMolecules Broadpharm Azido-PEG8-NHS ester 500mg 208940020 BP-21606 98 000 1204834-00-3 MFCD13184949 564 589 C23H40N4O12
Broadpharm Azido-PEG8-NHS ester 500mg 208940020 BP-21606 98 000 1204834-00-3 MFCD13184949 564 589 C23H40N4O12
Medchemexpress LLC Biotin-PEG7-maleimide | 1898221-65-2 | 99.4% | 745.88 g/mol | C33H55N5O12S | 25 MG
Biotin-PEG7-maleimide is a thiol-specific biotinylation reagent that introduces a biotin tag through a PEG7 spacer by reacting with free thiol (-SH) groups. It is used for selective cysteine labeling, affinity capture and detection, and for constructing drug-linker conjugates in bioconjugation workflows.
- Thiol-reactive maleimide group for selective cysteine labeling.
- PEG7 spacer provides flexibility and improved solubility.
- Biotin tag enables affinity capture and detection.
- High purity (99.4%) suitable for sensitive assays.
- Powder stable at -20°C for up to 3 years.
- Available as 25 MG quantity.
Medchemexpress LLC Digoxigenin NHS ester | 129273-26-3 | MFCD02093394 | 99.0% | 658.78 g/mol | C35H50N2O10 | 10 MG
Digoxigenin NHS ester is an activated N-hydroxysuccinimide (NHS) ester that conjugates the digoxigenin hapten to primary amines on proteins, peptides, or oligonucleotides under mild conditions. Supplied as a purified powder for biomolecule labeling and detection workflows, it is commonly used to prepare non-radioactive probes for in situ hybridization and immunodetection.
- High purity, typically 99.0%.
- Reacts with primary amines under mild conditions.
- Suitable for labeling proteins and oligonucleotides.
- Supplied as a stable powder with defined storage recommendations.
- Enables non-radioactive detection in molecular assays.
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 50 MG
Mal-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It is supplied for research use to facilitate conjugation between amine and thiol groups during antibody-drug conjugate (ADC) synthesis, and is provided as a solution for low-temperature storage.
- Non-cleavable 3-unit polyethylene glycol linker.
- Terminal maleimide and NHS ester functional groups for thiol and amine coupling.
- Suitable for antibody-drug conjugate (ADC) synthesis.
- Purity approximately 95.0%.
- Supplied as a solution; store at -20°C for up to 2 years.
Medchemexpress LLC Bis-PEG7-NHS ester | 1334170-02-3 | 98.0% | 620.60 g/mol | C26H40N2O15 | 250 MG
Bis-PEG7-NHS ester is a bifunctional PEG-based linker bearing two N-hydroxysuccinimide (NHS) ester groups. It is used as a building block in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs), offering a hydrophilic spacer and amine-reactive termini for conjugation chemistry.
- Contains two NHS ester functional groups for amine coupling.
- PEG7 spacer increases solubility in aqueous media.
- Suitable for ADC and PROTAC linker synthesis.
- Analytical purity: 98.0%.
- Molecular weight: 620.60 g/mol; molecular formula: C26H40N2O15.
- Store at -20°C; stable for extended storage under recommended conditions.
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 | C16H20N2O9 | 10 MG
Mal-PEG3-C1-NHS ester is a non-cleavable three-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester functional group, used to conjugate payloads to antibodies during antibody-drug conjugate synthesis. It is supplied as premeasured vials in DMSO to simplify dosing and handling in bioconjugation workflows.
- Non-cleavable three-unit PEG linker for bioconjugation.
- Maleimide reacts selectively with thiol groups; NHS ester reacts with primary amines.
- Supplied pre-dissolved in DMSO at 260.19 mM for convenient dosing.
- High purity suitable for research applications (95.0%).
- Colorless to light yellow solution stable at -20°C for up to 2 years when stored as directed.
Medchemexpress LLC DBCO-Biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g/mol | C28H30N4O3S | 100MG
DBCO-Biotin is a dibenzocyclooctyne-linked biotin reagent designed for copper-free click chemistry and efficient biotinylation of azide-functionalized molecules. It is used for catalyst-free conjugation in labeling, enrichment, and linker assembly workflows, including PROTAC synthesis. The reagent is DMSO-soluble and supplied with recommended storage conditions to preserve stability.